On Sacred Ground follows Daniel (William Mapother), a journalist and Afghanistan War military veteran, and Elliot (David Arquette), an oil company executive, who find themselves on opposite sides of the fight during the construction of the contentious pipeline. As the story unfolds, Daniel starts to align himself more with the Standing Rock Sioux Tribe than the oil company he was hired to write about favorably, and the two characters go down separate paths as the events unfold during one of the most heated protests and confrontation with Native American tribes in modern US history.